Differential methylation in Crohn’s disease

In a successful collaboration (Nimmo et al, 2012) with a clinical genetics group we provide the first evidence for characteristic patterns of DNA methylation in Crohn’s disease patients. Genes with altered methylation were disproportionately involved in immune system activation. Also across the genome methylation changes were highly enriched around loci implicated in GWAS, suggesting that alterations in methylation of key genes may contribute to disease.