We are a computational biology group based in the MRC Human Genetics Unit at the University of Edinburgh with broad interests in human disease genomics and molecular evolution. Our group performs computational analyses of large-scale genomic, transcriptomic and epigenomic datasets to shed light on the regulatory mechanisms encoded in the human genome. We also study the ways these mechanisms can be disrupted in diseases such as cancers. We collaborate with a wide range of experimental biologists and clinicians, from small groups of local researchers to international consortia. Our work is funded by the MRC and CSO.
Large structural variants impact tumour phenotype
March 23, 2021
For the past few years we’ve been working with Charlie Gourley’s lab in the CRUK Edinburgh Centre generating WGS data for high grade serous ovarian cancer (HGSOC) tumour samples – and the most recent product of this work, led by Dr AIlith Ewing, has recently surfaced in Clinical Cancer Research. This work establishes large (multi-megabase) … More Large structural variants impact tumour phenotype
