We are a computational biology group based in the MRC Human Genetics Unit at the University of Edinburgh with broad interests in human disease genomics and molecular evolution. Our group performs computational analyses of large-scale genomic, transcriptomic and epigenomic datasets to shed light on the regulatory mechanisms encoded in the human genome. We also study the ways these mechanisms can be disrupted in diseases such as cancers. We collaborate with a wide range of experimental biologists and clinicians, from small groups of local researchers to international consortia. Our work is funded by the MRC and CSO.
For almost 3 years we’ve had the pleasure of participating in the Liver Cancer Evolution (LCE) consortium, along with the labs of Duncan Odom, Paul Flicek, Nuria Lopez-Bigas and Martin Taylor – and today sees the publication of the first consortium paper in Nature. The Odom lab generated some unprecedented data, mapping genome and transcriptome … More Lesion segregation dominates early tumour genome evolution