We are a computational biology group based in the MRC Human Genetics Unit at the University of Edinburgh with broad interests in human disease genomics and molecular evolution. Our group develops novel computational analyses of large-scale genomic, transcriptomic and epigenomic datasets to shed light on regulatory mechanisms encoded in the human genome. We also study the ways these mechanisms can be disrupted in diseases such as cancers. We collaborate with a wide range of experimental biologists and clinicians, and from small groups of local researchers to international consortia.
We still know relatively little about the evolution of gene regulation in cancer. Vera’s study (Kaiser et al, 2016, PLOS Genet) is one of the biggest so far (~1500 tumour whole genomes) and shows that there are remarkably high mutation rates and rapid evolution at most (putatively) functional regulatory sites, and she sees this across … More The blind watch-breaker: regulatory evolution in cancers