The Semple Lab

Computational genomics at the MRC HGU

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We are a computational biology group based in the MRC Human Genetics Unit at the University of Edinburgh with broad interests in human disease genomics and molecular evolution. Our group develops novel computational analyses of large-scale genomic, transcriptomic and epigenomic datasets to shed light on regulatory mechanisms encoded in the human genome. We also study the ways these mechanisms can be disrupted in diseases such as cancers. We collaborate with a wide range of experimental biologists and clinicians, and from small groups of local researchers to international consortia.