The Semple Lab

Computational genomics at the MRC HGU


We are a computational biology group based in the MRC Human Genetics Unit at the University of Edinburgh with broad interests in human disease genomics and molecular evolution. Our group performs computational analyses of large-scale genomic, transcriptomic and epigenomic datasets to shed light on the regulatory mechanisms encoded in the human genome. We also study the ways these mechanisms can be disrupted in developmental disorders and in cancers. We collaborate with a wide range of experimental biologists and clinicians, from small groups of local researchers to international consortia. Our work is funded by the MRC and CSO.