We are a computational biology group based in the MRC Human Genetics Unit at the University of Edinburgh with broad interests in human disease genomics and molecular evolution. Our group performs computational analyses of large-scale genomic, transcriptomic and epigenomic datasets to shed light on the regulatory mechanisms encoded in the human genome. We also study the ways these mechanisms can be disrupted in diseases such as cancers. We collaborate with a wide range of experimental biologists and clinicians, from small groups of local researchers to international consortia. Our work is funded by the MRC and CSO.
Tracy’s work building models of DNA double strand break susceptibility finally emerges from review this week in Genome Biology. She shows that it is possible to make remarkably accurate models, predicting the frequency of breakage in a given region of the genome, using a variety of underlying chromatin features. These predicted frequencies from these models … More Modeling the breakome