We are a computational biology group based in the MRC Human Genetics Unit at the University of Edinburgh with broad interests in human disease genomics and molecular evolution. Our group performs computational analyses of large-scale genomic, transcriptomic and epigenomic datasets to shed light on the regulatory mechanisms encoded in the human genome. We also study the ways these mechanisms can be disrupted in diseases such as cancers. We collaborate with a wide range of experimental biologists and clinicians, from small groups of local researchers to international consortia. Our work is funded by the MRC and CSO.
For the past couple of years we’ve been studying the unusual genetics of the Shetland islands with Jim Wilson’s group. Jim has a long history of studying the isolated populations of the Scottish Northern Isles, but we’ve just published the first study that is based upon whole genome sequencing (WGS), comparing Shetland (n=500) and mainland … More Northern exposure