The Semple Lab

Stuart’s developed a clever new approach to time series data (Aitken et al, 2015), fitting expression profiles over time to a series of archetypical models or ‘kinetic signatures’. Unlike the dominant forms of analysis (clustering, differential expression between time points) this allows us to detect profiles of interest even if the profile of interest is entirely unique or involves lowly expressed transcripts. That turns out to be particularly handy when studying ncRNA dynamics.